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α9‐ and α7‐containing receptors mediate the pro‐proliferative effects of nicotine in the A549 adenocarcinoma cell line
Author(s) -
Mucchietto Vanessa,
Fasoli Francesca,
Pucci Susanna,
Moretti Milena,
Benfante Roberta,
Maroli Annalisa,
Di Lascio Simona,
Bolchi Cristiano,
Pallavicini Marco,
Dowell Cheryl,
McIntosh Michael,
Clementi Francesco,
Gotti Cecilia
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13954
Subject(s) - nicotine , a549 cell , nicotinic agonist , cell growth , pharmacology , receptor , cancer research , methyllycaconitine , cell culture , acetylcholine receptor , biology , microbiology and biotechnology , chemistry , nicotinic acetylcholine receptor , neuroscience , biochemistry , genetics
Tobacco smoke contains many classes of carcinogens and although nicotine is unable to initiate tumourigenesis in humans and rodents, it promotes tumour growth and metastasis in lung tumours by acting on neuronal nicotinic ACh receptors (nAChRs). The aim of this study was to identify molecularly, biochemically and pharmacologically which nAChR subtypes are expressed and functionally activated by nicotine in lung cancer cell lines.