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l ‐Homocysteine‐induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia
Author(s) -
Leng YiPing,
Ma YeShuo,
Li XiaoGang,
Chen RuiFang,
Zeng PingYu,
Li XiaoHui,
Qiu Chengfeng,
Li YaPei,
Zhang Zhen,
Chen Alex F
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - Slovenian
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13920
Subject(s) - cathepsin s , inflammation , cathepsin , homocysteine , cathepsin k , cathepsin l1 , downregulation and upregulation , chemistry , cathepsin d , cathepsin h , microbiology and biotechnology , biology , cancer research , immunology , biochemistry , in vitro , enzyme , osteoclast , gene
Vascular inflammation, including the expression of inflammatory cytokines in endothelial cells, plays a critical role in hyperhomocysteinaemia-associated vascular diseases. Cathepsin V, specifically expressed in humans, is involved in vascular diseases through its elastolytic and collagenolytic activities. The aim of this study was to determine the effects of cathepsin V on l-homocysteine-induced vascular inflammation.