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Inhibition of human N‐ and T‐type calcium channels by an ortho ‐phenoxyanilide derivative, MONIRO‐1
Author(s) -
McArthur Jeffrey R,
Motin Leonid,
Gleeson Ellen C,
Spiller Sandro,
Lewis Richard J,
Duggan Peter J,
Tuck Kellie L,
Adams David J
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13910
Subject(s) - voltage dependent calcium channel , t type calcium channel , calcium channel , chemistry , potency , calcium , electrophysiology , pharmacology , stimulation , patch clamp , n type calcium channel , l type calcium channel , biophysics , neuroscience , medicine , biology , in vitro , biochemistry , organic chemistry
Voltage-gated calcium channels are involved in nociception in the CNS and in the periphery. N-type (Ca v 2.2) and T-type (Ca v 3.1, Ca v 3.2 and Ca v 3.3) voltage-gated calcium channels are particularly important in studying and treating pain and epilepsy.