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Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation
Author(s) -
Bombardo Marta,
Malagola Ermanno,
Chen Rong,
Rudnicka Alina,
Graf Rolf,
Sonda Sabrina
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13867
Subject(s) - acinar cell , ibuprofen , inflammation , ceruletide , pancreatitis , cell growth , medicine , pancreas , in vivo , diclofenac , endocrinology , pharmacology , cancer research , cholecystokinin , chemistry , biology , receptor , biochemistry , microbiology and biotechnology
Nonsteroidal anti-inflammatory drugs (NSAIDs) are administered to manage the pain typically found in patients suffering from pancreatitis. NSAIDs also display anti-proliferative activity against cancer cells; however, their effects on normal, untransformed cells are poorly understood. Here, we evaluated whether NSAIDs inhibit the proliferation of pancreatic acinar cells during the development of acute pancreatitis.