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Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3‐dependent manner
Author(s) -
Meng Guoliang,
Liu Jieqiong,
Liu Shangmin,
Song Qiuyi,
Liu Lulu,
Xie Liping,
Han Yi,
Ji Yong
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - Italian
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13861
Subject(s) - sirt3 , mitochondrion , fis1 , oxidative stress , medicine , endocrinology , chemistry , microbiology and biotechnology , mfn2 , mitochondrial fusion , biology , sirtuin , biochemistry , mitochondrial dna , acetylation , gene
Hydrogen sulfide (H 2 S) is a gaseous signal molecule with antioxidative properties. Sirtuin 3 (SIRT3) is closely associated with mitochondrial function and oxidative stress. The study was to investigate whether and how H 2 S improved myocardial hypertrophy via a SIRT3-dependent manner.