Peripheral inflammation affects modulation of nociceptive synaptic transmission in the spinal cord induced by N‐arachidonoylphosphatidylethanolamine | Zendy

Nerandzic Vladimir | Zendy; Mrozkova Petra | Zendy; Adamek Pavel | Zendy; Spicarova Diana | Zendy; Nagy Istvan | Zendy; Palecek Jiri | Zendy

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Peripheral inflammation affects modulation of nociceptive synaptic transmission in the spinal cord induced by N‐arachidonoylphosphatidylethanolamine

Author(s) -

Nerandzic Vladimir,

Mrozkova Petra,

Adamek Pavel,

Spicarova Diana,

Nagy Istvan,

Palecek Jiri

Publication year - 2018

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.13849

Subject(s) - anandamide , trpv1 , endocannabinoid system , cannabinoid receptor , chemistry , cannabinoid , pharmacology , neurotransmission , nociception , excitatory postsynaptic potential , hyperalgesia , neuroscience , antagonist , receptor , medicine , biology , transient receptor potential channel , biochemistry

Endocannabinoids play an important role in modulating spinal nociceptive signalling, crucial for the development of pain. The cannabinoid CB 1 receptor and the TRPV1 cation channel are both activated by the endocannabinoid anandamide, a product of biosynthesis from the endogenous lipid precursor N-arachidonoylphosphatidylethanolamine (20:4-NAPE). Here, we report CB 1 receptor- and TRPV1-mediated effects of 20:4-NAPE on spinal synaptic transmission in control and inflammatory conditions.

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