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Peripheral inflammation affects modulation of nociceptive synaptic transmission in the spinal cord induced by N‐arachidonoylphosphatidylethanolamine
Author(s) -
Nerandzic Vladimir,
Mrozkova Petra,
Adamek Pavel,
Spicarova Diana,
Nagy Istvan,
Palecek Jiri
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13849
Subject(s) - anandamide , endocannabinoid system , trpv1 , cannabinoid receptor , cannabinoid , chemistry , neurotransmission , excitatory postsynaptic potential , pharmacology , depolarization induced suppression of inhibition , neuroscience , nociception , hyperalgesia , inhibitory postsynaptic potential , antagonist , receptor , biology , transient receptor potential channel , biochemistry
Endocannabinoids play an important role in modulating spinal nociceptive signalling, crucial for the development of pain. The cannabinoid CB 1 receptor and the TRPV1 cation channel are both activated by the endocannabinoid anandamide, a product of biosynthesis from the endogenous lipid precursor N-arachidonoylphosphatidylethanolamine (20:4-NAPE). Here, we report CB 1 receptor- and TRPV1-mediated effects of 20:4-NAPE on spinal synaptic transmission in control and inflammatory conditions.