Dietary salt blunts vasodilation by stimulating epithelial sodium channels in endothelial cells from salt‐sensitive Dahl rats | Zendy

Wang ZiRui | Zendy; Liu HuiBin | Zendy; Sun YingYing | Zendy; Hu QingQing | Zendy; Li YuXia | Zendy; Zheng WeiWan | Zendy; Yu ChangJiang | Zendy; Li XinYuan | Zendy; Wu MingMing | Zendy; Song BinLin | Zendy; Mu JianJun | Zendy; Yuan ZuYi | Zendy; Zhang ZhiRen | Zendy; Ma HePing | Zendy

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Dietary salt blunts vasodilation by stimulating epithelial sodium channels in endothelial cells from salt‐sensitive Dahl rats

Author(s) -

Wang ZiRui,

Liu HuiBin,

Sun YingYing,

Hu QingQing,

Li YuXia,

Zheng WeiWan,

Yu ChangJiang,

Li XinYuan,

Wu MingMing,

Song BinLin,

Mu JianJun,

Yuan ZuYi,

Zhang ZhiRen,

Ma HePing

Publication year - 2018

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.13817

Subject(s) - epithelial sodium channel , aldosterone , endocrinology , medicine , myograph , mineralocorticoid receptor , eplerenone , amiloride , vasodilation , mineralocorticoid , endothelium , chemistry , sodium , organic chemistry

Our recent studies show that the reduced activity of epithelial sodium channels (ENaC) in endothelial cells accounts for the adaptation of vasculature to salt in Sprague-Dawley rats. The present study examines a hypothesis that enhanced ENaC activity mediates the loss of vasorelaxation in Dahl salt-sensitive (SS) rats.

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