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Dietary salt blunts vasodilation by stimulating epithelial sodium channels in endothelial cells from salt‐sensitive Dahl rats
Author(s) -
Wang ZiRui,
Liu HuiBin,
Sun YingYing,
Hu QingQing,
Li YuXia,
Zheng WeiWan,
Yu ChangJiang,
Li XinYuan,
Wu MingMing,
Song BinLin,
Mu JianJun,
Yuan ZuYi,
Zhang ZhiRen,
Ma HePing
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13817
Subject(s) - epithelial sodium channel , aldosterone , endocrinology , medicine , myograph , mineralocorticoid receptor , eplerenone , amiloride , vasodilation , mineralocorticoid , endothelium , chemistry , sodium , organic chemistry
Our recent studies show that the reduced activity of epithelial sodium channels (ENaC) in endothelial cells accounts for the adaptation of vasculature to salt in Sprague-Dawley rats. The present study examines a hypothesis that enhanced ENaC activity mediates the loss of vasorelaxation in Dahl salt-sensitive (SS) rats.