Premium
Adiponectin improves endothelial function in mesenteric arteries of rats fed a high‐fat diet: role of perivascular adipose tissue
Author(s) -
Sena Cristina M,
Pereira Ana,
Fernandes Rosa,
Letra Liliana,
Seiça Raquel M
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13756
Subject(s) - adiponectin , medicine , endocrinology , adipose tissue , adipokine , mesenteric arteries , enos , endothelial dysfunction , leptin , obesity , insulin resistance , nitric oxide synthase , nitric oxide , artery
Adiponectin, the most abundant peptide secreted by adipocytes, is involved in the regulation of energy metabolism and vascular physiology. Here, we have investigated the effects of exogenous administration of adiponectin on metabolism, vascular reactivity and perivascular adipose tissue (PVAT) of mesenteric arteries in Wistar rats fed a high-fat diet.