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β‐Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice
Author(s) -
Varga Zoltan V.,
Matyas Csaba,
Erdelyi Katalin,
Cinar Resat,
Nieri Daniela,
Chicca Andrea,
Nemeth Balazs Tamas,
Paloczi Janos,
Lajtos Tamas,
Corey Lukas,
Hasko Gyorgy,
Gao Bin,
Kunos George,
Gertsch Jürg,
Pacher Pal
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13722
Subject(s) - liver injury , inflammation , steatohepatitis , steatosis , medicine , oxidative stress , fatty liver , immunology , pharmacology , endocrinology , disease
β-Caryophyllene (BCP) is a plant-derived FDA approved food additive with anti-inflammatory properties. Some of its beneficial effects in vivo are reported to involve activation of cannabinoid CB 2 receptors that are predominantly expressed in immune cells. Here, we evaluated the translational potential of BCP using a well-established model of chronic and binge alcohol-induced liver injury.