Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis | Zendy

Skiba D S | Zendy; Nosalski R | Zendy; Mikolajczyk T P | Zendy; Siedlinski M | Zendy; Rios F J | Zendy; Montezano A C | Zendy; Jawien J | Zendy; Olszanecki R | Zendy; Korbut R | Zendy; CzesnikiewiczGuzik M | Zendy; Touyz R M | Zendy; Guzik T J | Zendy

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Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis

Author(s) -

Skiba D S,

Nosalski R,

Mikolajczyk T P,

Siedlinski M,

Rios F J,

Montezano A C,

Jawien J,

Olszanecki R,

Korbut R,

CzesnikiewiczGuzik M,

Touyz R M,

Guzik T J

Publication year - 2017

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.13685

Subject(s) - inflammation , apolipoprotein e , proinflammatory cytokine , chemokine , macrophage , angiotensin ii , foam cell , receptor , monocyte , endocrinology , medicine , chemistry , in vitro , biochemistry , disease

Inflammation plays a key role in atherosclerosis. The protective role of angiotensin 1-7 (Ang-(1-7)) in vascular pathologies suggested the therapeutic use of low MW, non-peptide Ang-(1-7) mimetics, such as AVE0991. The mechanisms underlying the vaso-protective effects of AVE0991, a Mas receptor agonist, remain to be explored.

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