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Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis
Author(s) -
Skiba D S,
Nosalski R,
Mikolajczyk T P,
Siedlinski M,
Rios F J,
Montezano A C,
Jawien J,
Olszanecki R,
Korbut R,
CzesnikiewiczGuzik M,
Touyz R M,
Guzik T J
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13685
Subject(s) - inflammation , apolipoprotein e , proinflammatory cytokine , chemokine , macrophage , angiotensin ii , foam cell , receptor , monocyte , endocrinology , medicine , chemistry , in vitro , biochemistry , disease
Inflammation plays a key role in atherosclerosis. The protective role of angiotensin 1-7 (Ang-(1-7)) in vascular pathologies suggested the therapeutic use of low MW, non-peptide Ang-(1-7) mimetics, such as AVE0991. The mechanisms underlying the vaso-protective effects of AVE0991, a Mas receptor agonist, remain to be explored.