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Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets
Author(s) -
Akoumianakis Ioannis,
Tarun Akansha,
Antoniades Charalambos
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13666
Subject(s) - adipose tissue , adiponectin , adipokine , paracrine signalling , regulator , pathogenesis , endocrine system , biology , medicine , bioinformatics , endocrinology , immunology , diabetes mellitus , insulin resistance , hormone , receptor , biochemistry , gene
Adipose tissue (AT) is an active endocrine organ with the ability to dynamically secrete a wide range of adipocytokines. Importantly, its secretory profile is altered in various cardiovascular disease states. AT surrounding vessels, or perivascular AT (PVAT), is recognized in particular as an important local regulator of vascular function and dysfunction. Specifically, PVAT has the ability to sense vascular paracrine signals and respond by secreting a variety of vasoactive adipocytokines. Due to the crucial role of PVAT in regulating many aspects of vascular biology, it may constitute a novel therapeutic target for the prevention and treatment of vascular disease pathogenesis. Signalling pathways in PVAT, such as those using adiponectin, H 2 S, glucagon-like peptide 1 or pro-inflammatory cytokines, are among the potential novel pharmacological therapeutic targets of PVAT.