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Development of a stretch‐induced neurotrauma model for medium‐throughput screening in vitro : identification of rifampicin as a neuroprotectant
Author(s) -
LópezGarcía Isabel,
Gerő Domokos,
Szczesny Bartosz,
Szoleczky Petra,
Olah Gabor,
Módis Katalin,
Zhang Kangling,
Gao Jungling,
Wu Ping,
Sowers Lawrence C,
DeWitt Doug,
Prough Donald S,
Szabo Csaba
Publication year - 2018
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13642
Subject(s) - neuroprotection , neurite , viability assay , pharmacology , cellular model , neural stem cell , mtt assay , apoptosis , chemistry , in vitro , microbiology and biotechnology , medicine , biology , biochemistry , stem cell
We hypothesized that an in vitro, stretch-based model of neural injury may be useful to identify compounds that decrease the cellular damage in neurotrauma.