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Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release
Author(s) -
Almabrouk Tarek A M,
Ugusman Azizah B,
Katwan Omar J,
Salt Ian P,
Kennedy Simon
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13633
Subject(s) - adiponectin , endocrinology , medicine , adipose tissue , ampk , cromakalim , vasodilation , vasoactive intestinal peptide , myograph , chemistry , neuropeptide , agonist , protein kinase a , biochemistry , insulin , insulin resistance , receptor , enzyme
Perivascular adipose tissue (PVAT) surrounds most blood vessels and secretes numerous active substances, including adiponectin, which produce a net anticontractile effect in healthy individuals. AMPK is a key mediator of cellular energy balance and may mediate the vascular effects of adiponectin. In this study, we investigated the role of AMPK within PVAT in mediating the anticontractile effect of PVAT.