Effects of anthocyanins on the prevention and treatment of cancer | Zendy

Lin BoWen | Zendy; Gong ChengChen | Zendy; Song HaiFei | Zendy; Cui YingYu | Zendy

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Effects of anthocyanins on the prevention and treatment of cancer

Author(s) -

Lin BoWen,

Gong ChengChen,

Song HaiFei,

Cui YingYu

Publication year - 2017

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.13627

Subject(s) - nutraceutical , cancer , in vivo , metastasis , apoptosis , antioxidant , cancer prevention , autophagy , biology , cell growth , cancer research , cell cycle , cancer cell , cell cycle checkpoint , pharmacology , bioinformatics , medicine , microbiology and biotechnology , biochemistry , genetics

Anthocyanins are a class of water-soluble flavonoids, which show a range of pharmacological effects, such as prevention of cardiovascular disease, obesity control and antitumour activity. Their potential antitumour effects are reported to be based on a wide variety of biological activities including antioxidant; anti-inflammation; anti-mutagenesis; induction of differentiation; inhibiting proliferation by modulating signal transduction pathways, inducing cell cycle arrest and stimulating apoptosis or autophagy of cancer cells; anti-invasion; anti-metastasis; reversing drug resistance of cancer cells and increasing their sensitivity to chemotherapy. In this review, the latest progress on the anticancer activities of anthocyanins and the underlying molecular mechanisms is summarized using data from basic research in vitro and in vivo, from clinical trials and taking into account theory and practice.

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