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Effects of anthocyanins on the prevention and treatment of cancer
Author(s) -
Lin BoWen,
Gong ChengChen,
Song HaiFei,
Cui YingYu
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13627
Subject(s) - nutraceutical , in vivo , cancer , apoptosis , antioxidant , metastasis , cancer research , cell growth , biology , cell cycle , autophagy , cancer prevention , pharmacology , cancer cell , cell cycle checkpoint , signal transduction , bioinformatics , medicine , microbiology and biotechnology , biochemistry , genetics
Anthocyanins are a class of water-soluble flavonoids, which show a range of pharmacological effects, such as prevention of cardiovascular disease, obesity control and antitumour activity. Their potential antitumour effects are reported to be based on a wide variety of biological activities including antioxidant; anti-inflammation; anti-mutagenesis; induction of differentiation; inhibiting proliferation by modulating signal transduction pathways, inducing cell cycle arrest and stimulating apoptosis or autophagy of cancer cells; anti-invasion; anti-metastasis; reversing drug resistance of cancer cells and increasing their sensitivity to chemotherapy. In this review, the latest progress on the anticancer activities of anthocyanins and the underlying molecular mechanisms is summarized using data from basic research in vitro and in vivo, from clinical trials and taking into account theory and practice.