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Proteinase activated receptor‐2 counterbalances the vascular effects of endothelin‐1 in fibrotic tight‐skin mice
Author(s) -
Roviezzo Fiorentina,
Brancaleone Vincenzo,
Mattera Iacono Valentina,
Bertolino Antonio,
De Cunto Giovanna,
Vellecco Valentina,
Lungarella Giuseppe,
Lucattelli Monica,
Cirino Giuseppe
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13618
Subject(s) - receptor , phenylephrine , endocrinology , vascular smooth muscle , medicine , endothelin receptor , endothelin 1 , aorta , biology , chemistry , smooth muscle , blood pressure
The majority of the severe vascular complications in fibrosis are a consequence of a deregulated activity of mediators controlling vasomotor tone. One of the most important of these mediators is endothelin-1 (ET-1). Here, we have investigated the role of proteinase-activated receptor 2 (PAR2) in the vascular dysfunction in a model of fibrosis, using tight-skin (Tsk) mice.