Proteinase activated receptor‐2 counterbalances the vascular effects of endothelin‐1 in fibrotic tight‐skin mice | Zendy

Roviezzo Fiorentina | Zendy; Brancaleone Vincenzo | Zendy; Mattera Iacono Valentina | Zendy; Bertolino Antonio | Zendy; De Cunto Giovanna | Zendy; Vellecco Valentina | Zendy; Lungarella Giuseppe | Zendy; Lucattelli Monica | Zendy; Cirino Giuseppe | Zendy

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Proteinase activated receptor‐2 counterbalances the vascular effects of endothelin‐1 in fibrotic tight‐skin mice

Author(s) -

Roviezzo Fiorentina,

Brancaleone Vincenzo,

Mattera Iacono Valentina,

Bertolino Antonio,

De Cunto Giovanna,

Vellecco Valentina,

Lungarella Giuseppe,

Lucattelli Monica,

Cirino Giuseppe

Publication year - 2017

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.13618

Subject(s) - receptor , phenylephrine , endocrinology , vascular smooth muscle , medicine , endothelin receptor , endothelin 1 , aorta , biology , chemistry , smooth muscle , blood pressure

The majority of the severe vascular complications in fibrosis are a consequence of a deregulated activity of mediators controlling vasomotor tone. One of the most important of these mediators is endothelin-1 (ET-1). Here, we have investigated the role of proteinase-activated receptor 2 (PAR2) in the vascular dysfunction in a model of fibrosis, using tight-skin (Tsk) mice.

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