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Glucagon‐like peptide‐1 receptor signalling reduces microvascular thrombosis, nitro‐oxidative stress and platelet activation in endotoxaemic mice
Author(s) -
Steven Sebastian,
Jurk Kerstin,
Kopp Maximilian,
KröllerSchön Swenja,
Mikhed Yuliya,
Schwierczek Kathrin,
Roohani Siyer,
Kashani Fatemeh,
Oelze Matthias,
Klein Thomas,
Tokalov Sergey,
Danckwardt Sven,
Strand Susanne,
Wenzel Philip,
Münzel Thomas,
Daiber Andreas
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13549
Subject(s) - liraglutide , platelet activation , glucagon like peptide 1 receptor , linagliptin , medicine , dipeptidyl peptidase 4 , receptor , pharmacology , platelet , endocrinology , inflammation , agonist , oxidative stress , receptor expression , sepsis , ccr2 , diabetes mellitus , chemokine , type 2 diabetes mellitus , chemokine receptor , type 2 diabetes
Excessive inflammation in sepsis causes microvascular thrombosis and thrombocytopenia associated with organ dysfunction and high mortality. The present studies aimed to investigate whether inhibition of dipeptidyl peptidase-4 (DPP-4) and supplementation with glucagon-like peptide-1 (GLP-1) receptor agonists improved endotoxaemia-associated microvascular thrombosis via immunomodulatory effects.