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Anti‐inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions
Author(s) -
Maione Francesco,
Cantone Vincenza,
Pace Simona,
Chini Maria Giovanna,
Bisio Angela,
Romussi Giovanni,
Pieretti Stefano,
Werz Oliver,
Koeberle Andreas,
Mascolo Nicola,
Bifulco Giuseppe
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13545
Subject(s) - carnosic acid , eicosanoid , chemistry , pharmacology , in vivo , in silico , enzyme , biochemistry , prostaglandin e2 , prostaglandin , arachidonic acid , biology , antioxidant , microbiology and biotechnology , gene , endocrinology
The diterpenoids carnosol (CS) and carnosic acid (CA) from Salvia spp. exert prominent anti-inflammatory activities but their molecular mechanisms remained unclear. Here we investigated the effectiveness of CS and CA in inflammatory pain and the cellular interference with their putative molecular targets.