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Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor
Author(s) -
Ang Sheng Y,
Hutchinson Dana S,
Patil Nitin,
Evans Bronwyn A,
Bathgate Ross A D,
Halls Michelle L,
Hossain Mohammed A,
Summers Roger J,
Kocan Martina
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13522
Subject(s) - receptor , relaxin , biology , forskolin , signal transduction , g protein coupled receptor , pertussis toxin , mapk/erk pathway , microbiology and biotechnology , biochemistry , g protein
Insulin-like peptide 5 (INSL5) is a two-chain, three-disulfide-bonded peptide of the insulin/relaxin superfamily, uniquely expressed in enteroendocrine L-cells of the colon. It is the cognate ligand of relaxin family peptide RXFP4 receptor that is mainly expressed in the colorectum and enteric nervous system. This study identifies new signalling pathways activated by INSL5 acting on RXFP4 receptors.