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Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management
Author(s) -
Jankovic Aleksandra,
Korac Aleksandra,
Buzadzic Biljana,
Stancic Ana,
Otasevic Vesna,
Ferdinandy Péter,
Daiber Andreas,
Korac Bato
Publication year - 2017
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13498
Subject(s) - adipose tissue , superoxide , oxidative stress , reactive oxygen species , diabetes mellitus , superoxide dismutase , nitric oxide , oxidative phosphorylation , endocrinology , metabolic syndrome , chemistry , medicine , biology , biochemistry , enzyme
Insulin sensitivity and metabolic homeostasis depend on the capacity of adipose tissue to take up and utilize excess glucose and fatty acids. The key aspects that determine the fuel-buffering capacity of adipose tissue depend on the physiological levels of the small redox molecule, nitric oxide (NO). In addition to impairment of NO synthesis, excessive formation of the superoxide anion (О 2 •- ) in adipose tissue may be an important interfering factor diverting the signalling of NO and other reactive oxygen and nitrogen species in obesity, resulting in metabolic dysfunction of adipose tissue over time. Besides its role in relief from superoxide burst, enhanced NO signalling may be responsible for the therapeutic benefits of different superoxide dismutase mimetics, in obesity and experimental diabetes models. This review summarizes the role of NO in adipose tissue and highlights the effects of NO/О 2 •- ratio 'teetering' as a promising pharmacological target in the metabolic syndrome.