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High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice
Author(s) -
Zemdegs Juliane,
Quesseveur Gaël,
Jarriault David,
Pénicaud Luc,
Fioramonti Xavier,
Guiard Bruno P.
Publication year - 2016
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13343
Subject(s) - escitalopram , anxiogenic , endocrinology , medicine , microdialysis , antidepressant , serotonergic , type 2 diabetes , reuptake inhibitor , serotonin , psychology , diabetes mellitus , anxiolytic , hippocampus , receptor , dopamine
The link between type 2 diabetes mellitus (T2DM) and depression is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic-like/depressive-like symptoms or alter the efficacy of antidepressant drugs remains poorly documented. This study explored the influence of T2DM on emotionality and proposed a therapeutic strategy that might be used in depressed diabetic patients.