High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice | Zendy

Zemdegs Juliane | Zendy; Quesseveur Gaël | Zendy; Jarriault David | Zendy; Pénicaud Luc | Zendy; Fioramonti Xavier | Zendy; Guiard Bruno P. | Zendy

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High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice

Author(s) -

Zemdegs Juliane,

Quesseveur Gaël,

Jarriault David,

Pénicaud Luc,

Fioramonti Xavier,

Guiard Bruno P.

Publication year - 2016

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.13343

Subject(s) - escitalopram , anxiogenic , endocrinology , medicine , microdialysis , antidepressant , serotonergic , type 2 diabetes , type 2 diabetes mellitus , psychology , serotonin , anxiolytic , diabetes mellitus , hippocampus , receptor , dopamine

The link between type 2 diabetes mellitus (T2DM) and depression is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic-like/depressive-like symptoms or alter the efficacy of antidepressant drugs remains poorly documented. This study explored the influence of T2DM on emotionality and proposed a therapeutic strategy that might be used in depressed diabetic patients.

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