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High‐density lipoprotein inhibits human M1 macrophage polarization through redistribution of caveolin‐1
Author(s) -
Lee Man K S,
Moore XiaoLei,
Fu Yi,
AlSharea Annas,
Dragoljevic Dragana,
FernandezRojo Manuel A,
Parton Robert,
Sviridov Dmitri,
Murphy Andrew J,
ChinDusting Jaye P F
Publication year - 2016
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13319
Subject(s) - macrophage , inflammation , microbiology and biotechnology , m2 macrophage , phenotype , macrophage polarization , monocyte , cholesterol , biology , high density lipoprotein , tumor necrosis factor alpha , chemistry , endocrinology , immunology , in vitro , biochemistry , gene
Monocyte-derived macrophages are critical in the development of atherosclerosis and can adopt a wide range of functional phenotypes depending on their surrounding milieu. High-density lipoproteins (HDLs) have many cardio-protective properties including potent anti-inflammatory effects. We investigated the effects of HDL on human macrophage phenotype and the mechanisms by which these occur.