Premium
Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase‐activated receptor‐2
Author(s) -
Muley Milind M,
Reid Allison R,
Botz Bálint,
Bölcskei Kata,
Helyes Zsuzsanna,
McDougall Jason J
Publication year - 2016
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13237
Subject(s) - inflammation , elastase , receptor , neutrophil elastase , medicine , immunology , chemistry , endocrinology , enzyme , biochemistry
Neutrophil elastase plays a crucial role in arthritis. Here, its potential in triggering joint inflammation and pain was assessed, and whether these effects were mediated by proteinase-activated receptor-2 (PAR2).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom