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Neutrophil elastase induces inflammation and pain in mouse knee joints via activation of proteinase‐activated receptor‐2
Author(s) -
Muley Milind M,
Reid Allison R,
Botz Bálint,
Bölcskei Kata,
Helyes Zsuzsanna,
McDougall Jason J
Publication year - 2016
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13237
Subject(s) - neutrophil elastase , elastase , inflammation , medicine , neutrophil extracellular traps , arthritis , pharmacology , pancreatic elastase , immunology , chemistry , enzyme , biochemistry
Neutrophil elastase plays a crucial role in arthritis. Here, its potential in triggering joint inflammation and pain was assessed, and whether these effects were mediated by proteinase-activated receptor-2 (PAR2).