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Selective activation of D 1 dopamine receptors impairs sensorimotor gating in L ong– E vans rats
Author(s) -
Mosher Laura J,
Frau Roberto,
Pardu Alessandra,
Pes Romina,
Devoto Paola,
Bortolato Marco
Publication year - 2016
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13232
Subject(s) - prepulse inhibition , sensory gating , gating , receptor , neuroscience , dopamine , moro reflex , agonist , neurotransmitter , startle response , dopamine receptor , reflex , psychology , schizophrenia (object oriented programming) , medicine , psychiatry
Sensorimotor gating is a perceptual process aimed at filtering out irrelevant information. In humans and animal models, this function can be operationally measured through the prepulse inhibition (PPI) of the acoustic startle reflex. Notably, PPI deficits are associated with numerous neuropsychiatric conditions characterized by gating disturbances, including schizophrenia and Tourette syndrome. Ample evidence has shown that dopamine plays a key role in PPI regulation and, in particular, rodent studies indicate that this neurotransmitter modulates PPI through D1 and D2 dopamine receptors. In mice, the relative contributions of these two families of receptors are strain-dependent. Conversely, the role of D1 receptors in the regulation of PPI across different rat strains remains unclear.