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Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt‐induced hypertension in mice
Author(s) -
Krishnan S M,
Dowling J K,
Ling Y H,
Diep H,
Chan C T,
Ferens D,
Kett M M,
Pinar A,
Samuel C S,
Vinh A,
Arumugam T V,
Hewitson T D,
KempHarper B K,
Robertson A A B,
Cooper M A,
Latz E,
Mansell A,
Sobey C G,
Drummond G R
Publication year - 2016
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13230
Subject(s) - inflammasome , inflammation , endocrinology , medicine , caspase 1 , kidney , fibrosis , chemistry
Inflammasomes are multimeric complexes that facilitate caspase-1-mediated processing of the pro-inflammatory cytokines IL-1β and IL-18. Clinical hypertension is associated with renal inflammation and elevated circulating levels of IL-1β and IL-18. Therefore, we investigated whether hypertension in mice is associated with increased expression and/or activation of the inflammasome in the kidney, and if inhibition of inflammasome activity reduces BP, markers of renal inflammation and fibrosis.