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Constrictor prostanoids and uridine adenosine tetraphosphate: vascular mediators and therapeutic targets in hypertension and diabetes
Author(s) -
Matsumoto Takayuki,
Goulopoulou Styliani,
Taguchi Kumiko,
Tostes Rita C,
Kobayashi Tsuneo
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13205
Subject(s) - medicine , diabetes mellitus , endothelium , endothelial dysfunction , endocrinology , adenosine , pathophysiology of hypertension , vasodilation , diabetic angiopathy , vascular smooth muscle , prostanoid , blood pressure , prostaglandin , smooth muscle
Vascular dysfunction plays a pivotal role in the development of systemic complications associated with arterial hypertension and diabetes. The endothelium, or more specifically, various factors derived from endothelial cells tightly regulate vascular function, including vascular tone. In physiological conditions, there is a balance between endothelium‐derived factors, that is, relaxing factors (endothelium‐derived relaxing factors; EDRF s) and contracting factors (endothelium‐derived contracting factors; EDCF s), which mediate vascular homeostasis. However, in disease states, such as diabetes and arterial hypertension, there is an imbalance between EDRF and EDCF , with a reduction of EDRF signalling and an increase of EDCF signalling. Among EDCFs , COX ‐derived vasoconstrictor prostanoids play an important role in the development of vascular dysfunction associated with hypertension and diabetes. Moreover, uridine adenosine tetraphosphate ( U p 4 A ), identified as an EDCF in 2005, also modulates vascular function. However, the role of U p 4 A in hypertension‐ and diabetes‐associated vascular dysfunction is unclear. In the present review, we focused on experimental and clinical evidence that implicate these two EDCFs (vasoconstrictor prostanoids and U p 4 A ) in vascular dysfunction associated with hypertension and diabetes.

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