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Aldosterone down‐regulates the slowly activated delayed rectifier potassium current in adult guinea pig cardiomyocytes
Author(s) -
Lv Yankun,
Bai Song,
Zhang Hua,
Zhang Hongxue,
Meng Jing,
Li Li,
Xu Yanfang
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13163
Subject(s) - aldosterone , medicine , endocrinology , spironolactone , mineralocorticoid receptor , mineralocorticoid , patch clamp , potassium channel , inward rectifier potassium ion channel , electrophysiology , chemistry , biology , ion channel , receptor
There is emerging evidence that the mineralocorticoid hormone aldosterone is associated with arrhythmias in cardiovascular disease. However, the effect of aldosterone on the slowly activated delayed rectifier potassium current (IK s ) remains poorly understood. The present study was designed to investigate the modulation of IK s by aldosterone.