The anti‐inflammatory mediator palmitoylethanolamide enhances the levels of 2‐arachidonoyl‐glycerol and potentiates its actions at TRPV1 cation channels | Zendy

Petrosino Stefania | Zendy; Schiano Moriello Aniello | Zendy; Cerrato Santiago | Zendy; Fusco Mariella | Zendy; Puigdemont Anna | Zendy; De Petrocellis Luciano | Zendy; Di Marzo Vincenzo | Zendy

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The anti‐inflammatory mediator palmitoylethanolamide enhances the levels of 2‐arachidonoyl‐glycerol and potentiates its actions at TRPV1 cation channels

Author(s) -

Petrosino Stefania,

Schiano Moriello Aniello,

Cerrato Santiago,

Fusco Mariella,

Puigdemont Anna,

De Petrocellis Luciano,

Di Marzo Vincenzo

Publication year - 2016

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.13084

Subject(s) - trpv , palmitoylethanolamide , trpv1 , chemistry , endocannabinoid system , pharmacology , anandamide , transient receptor potential channel , agonist , 2 arachidonoylglycerol , cannabinoid receptor , capsaicin , capsazepine , hek 293 cells , biochemistry , receptor , medicine

Palmitoylethanolamide (PEA) is an endogenous congener of anandamide and potentiates its actions at cannabinoid CB1 and CB2 receptors, and at transient receptor potential vanilloid type-1 (TRPV1) channels. The other endocannabinoid, 2-arachidonoylglycerol (2-AG), was recently suggested to act as a TRPV1 channel agonist. We investigated if PEA enhanced levels of 2-AG in vitro or in vivo and 2-AG activity at TRPV1 channels.

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