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The anti‐inflammatory mediator palmitoylethanolamide enhances the levels of 2‐arachidonoyl‐glycerol and potentiates its actions at TRPV1 cation channels
Author(s) -
Petrosino Stefania,
Schiano Moriello Aniello,
Cerrato Santiago,
Fusco Mariella,
Puigdemont Anna,
De Petrocellis Luciano,
Di Marzo Vincenzo
Publication year - 2016
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13084
Subject(s) - trpv , palmitoylethanolamide , trpv1 , chemistry , endocannabinoid system , pharmacology , anandamide , transient receptor potential channel , agonist , 2 arachidonoylglycerol , cannabinoid receptor , capsaicin , capsazepine , hek 293 cells , biochemistry , receptor , medicine
Palmitoylethanolamide (PEA) is an endogenous congener of anandamide and potentiates its actions at cannabinoid CB1 and CB2 receptors, and at transient receptor potential vanilloid type-1 (TRPV1) channels. The other endocannabinoid, 2-arachidonoylglycerol (2-AG), was recently suggested to act as a TRPV1 channel agonist. We investigated if PEA enhanced levels of 2-AG in vitro or in vivo and 2-AG activity at TRPV1 channels.