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Cryptotanshinone, an orally bioactive herbal compound from D anshen, attenuates atherosclerosis in apolipoprotein E ‐deficient mice: role of lectin‐like oxidized LDL receptor‐1 ( LOX ‐1)
Author(s) -
Liu Zhiping,
Xu Suowen,
Huang Xiaoyang,
Wang Jiaojiao,
Gao Si,
Li Hong,
Zhou Changhua,
Ye Jiantao,
Chen Shaorui,
Jin ZhengGen,
Liu Peiqing
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13068
Subject(s) - chemistry , pharmacology , apolipoprotein b , lectin , biochemistry , medicine , cholesterol
Cryptotanshinone (CTS) is a major bioactive diterpenoid isolated from Danshen, an eminent medicinal herb that is used to treat cardiovascular disorders in Asian medicine. However, it is not known whether CTS can prevent experimental atherosclerosis. The present study was designed to investigate the protective effects of CTS on atherosclerosis and its molecular mechanisms of action.