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Renal effects of chronic pharmacological manipulation of CB 2 receptors in rats with diet‐induced obesity
Author(s) -
Jenkin K A,
O'Keefe L,
Simcocks A C,
Briffa J F,
Mathai M L,
McAinch A J,
Hryciw D H
Publication year - 2016
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13056
Subject(s) - medicine , endocrinology , renal function , creatinine , kidney , receptor , nephropathy , diabetes mellitus
In diabetic nephropathy agonism of CB2 receptors reduces albuminuria and podocyte loss; however, the role of CB2 receptors in obesity-related nephropathy is unknown. The aim of this study was to determine the role of CB2 receptors in a model of diet-induced obesity (DIO) and characterize the hallmark signs of renal damage in response to agonism (AM1241) and antagonism (AM630) of CB2 receptors.