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Genistein alleviates pressure overload‐induced cardiac dysfunction and interstitial fibrosis in mice
Author(s) -
Qin Wei,
Du Ning,
Zhang Longyin,
Wu Xianxian,
Hu Yingying,
Li Xiaoguang,
Shen Nannan,
Li Yang,
Yang Baofeng,
Xu Chaoqian,
Fang Zhiwei,
Lu Yanjie,
Zhang Yong,
Du Zhimin
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.13002
Subject(s) - pressure overload , genistein , cardiac fibrosis , myofibroblast , fibrosis , endocrinology , medicine , cardiac function curve , cancer research , heart failure , muscle hypertrophy , biology , cardiac hypertrophy
Pressure overload-induced cardiac interstitial fibrosis is viewed as a major cause of heart failure in patients with hypertension or aorta atherosclerosis. The purpose of this study was to investigate the effects and the underlying mechanisms of genistein, a natural phytoestrogen found in soy bean extract, on pressure overload-induced cardiac fibrosis.