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Noble gases as cardioprotectants – translatability and mechanism
Author(s) -
Smit Kirsten F,
Weber Nina C,
Hollmann Markus W,
Preckel Benedikt
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12994
Subject(s) - ischemia , stimulus (psychology) , neuroscience , cardioprotection , inert gas , medicine , chemistry , cardiology , psychology , psychotherapist , organic chemistry
Several noble gases, although classified as inert substances, exert a tissue-protective effect in different experimental models when applied before organ ischaemia as an early or late preconditioning stimulus, after ischaemia as a post-conditioning stimulus or when given in combination before, during and/or after ischaemia. A wide range of organs can be protected by these inert substances, in particular cardiac and neuronal tissue. In this review we summarize the data on noble gas-induced cardioprotection, focusing on the underlying protective mechanisms. We will also look at translatability of experimental data to the clinical situation.