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Aspirin enhances protective effect of fish oil against thrombosis and injury‐induced vascular remodelling
Author(s) -
Gong Yanjun,
Lin Minghui,
Piao Lingjuan,
Li Xinzhi,
Yang Fei,
Zhang Jian,
Xiao Bing,
Zhang Qingli,
Song WenLiang,
Yin Huiyong,
Zhu Li,
Funk Colin D,
Yu Ying
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12986
Subject(s) - aspirin , medicine , platelet activation , pharmacology , platelet , fish oil , proinflammatory cytokine , inflammation , chemistry , biology , fishery , fish <actinopterygii>
Although aspirin (acetylsalicylic acid) is commonly used to prevent ischaemic events in patients with coronary artery disease, many patients fail to respond to aspirin treatment. Dietary fish oil (FO), containing ω3 polyunsaturated fatty acids (PUFAs), has anti-inflammatory and cardio-protective properties, such as lowering cholesterol and modulating platelet activity. The objective of the present study was to investigate the potential additional effects of aspirin and FO on platelet activity and vascular response to injury.