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Dopamine receptors – IUPHAR R eview 13
Author(s) -
Beaulieu JeanMartin,
Espinoza Stefano,
Gainetdinov Raul R
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12906
Subject(s) - dopamine , g protein coupled receptor , dopamine receptor d3 , dopamine receptor , d2 like receptor , d1 like receptor , receptor , neuroscience , dopamine receptor d2 , g protein coupled receptor kinase , biology , pharmacology , biochemistry
The variety of physiological functions controlled by dopamine in the brain and periphery is mediated by the D 1 , D 2 , D 3 , D 4 and D 5 dopamine GPCRs . Drugs acting on dopamine receptors are significant tools for the management of several neuropsychiatric disorders including schizophrenia, bipolar disorder, depression and P arkinson's disease. Recent investigations of dopamine receptor signalling have shown that dopamine receptors, apart from their canonical action on cAMP ‐mediated signalling, can regulate a myriad of cellular responses to fine‐tune the expression of dopamine‐associated behaviours and functions. Such signalling mechanisms may involve alternate G protein coupling or non‐ G protein mechanisms involving ion channels, receptor tyrosine kinases or proteins such as β ‐arrestins that are classically involved in GPCR desensitization. Another level of complexity is the growing appreciation of the physiological roles played by dopamine receptor heteromers. Applications of new in vivo techniques have significantly furthered the understanding of the physiological functions played by dopamine receptors. Here we provide an update of the current knowledge regarding the complex biology, signalling, physiology and pharmacology of dopamine receptors.