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Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II ‐induced hypertensive heart disease in rats
Author(s) -
Snijder P M,
Frenay A R,
Boer R A,
Pasch A,
Hillebrands J L,
Leuvenink H G D,
Goor H
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12825
Subject(s) - cardiac fibrosis , angiotensin ii , medicine , oxidative stress , endocrinology , sodium hydrosulfide , hypertensive heart disease , atrial natriuretic peptide , fibrosis , pharmacology , heart failure , chemistry , blood pressure , hydrogen sulfide , sulfur , organic chemistry
Hypertension is an important mediator of cardiac damage and remodelling. Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter with cardioprotective properties. However, it is not yet in clinical use. We, therefore, investigated the protective effects of sodium thiosulfate (STS), a clinically applicable H2 S donor substance, in angiotensin II (Ang II)-induced hypertensive cardiac disease in rats.