Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin  II ‐induced hypertensive heart disease in rats | Zendy

Snijder P M | Zendy; Frenay A R | Zendy; Boer R A | Zendy; Pasch A | Zendy; Hillebrands J L | Zendy; Leuvenink H G D | Zendy; Goor H | Zendy

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Exogenous administration of thiosulfate, a donor of hydrogen sulfide, attenuates angiotensin II ‐induced hypertensive heart disease in rats

Author(s) -

Snijder P M,

Frenay A R,

Boer R A,

Pasch A,

Hillebrands J L,

Leuvenink H G D,

Goor H

Publication year - 2015

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.12825

Subject(s) - cardiac fibrosis , angiotensin ii , medicine , oxidative stress , endocrinology , sodium hydrosulfide , fibrosis , atrial natriuretic peptide , renin–angiotensin system , sodium thiosulfate , hypertensive heart disease , saline , chemistry , pharmacology , heart failure , hydrogen sulfide , blood pressure , sulfur , organic chemistry , inorganic chemistry

Hypertension is an important mediator of cardiac damage and remodelling. Hydrogen sulfide (H2S) is an endogenously produced gasotransmitter with cardioprotective properties. However, it is not yet in clinical use. We, therefore, investigated the protective effects of sodium thiosulfate (STS), a clinically applicable H2 S donor substance, in angiotensin II (Ang II)-induced hypertensive cardiac disease in rats.

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