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Specific regions display altered grey matter volume in μ‐opioid receptor knockout mice: MRI voxel‐based morphometry
Author(s) -
Sasaki Kazumasu,
Sumiyoshi Akira,
aka Hiroi,
Kasahara Yoshiyuki,
Ikeda Kazutaka,
Hall F Scott,
Uhl George R,
Watanabe Masahiko,
Kawashima Ryuta,
Sora Ichiro
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12807
Subject(s) - periaqueductal gray , olfactory bulb , grey matter , granule cell , neuroscience , nucleus accumbens , cerebellum , granular layer , thalamus , biology , anatomy , chemistry , endocrinology , central nervous system , dentate gyrus , magnetic resonance imaging , midbrain , white matter , medicine , radiology
μ Opioid receptor knockout (MOP-KO) mice display several behavioural differences from wild-type (WT) littermates including differential responses to nociceptive stimuli. Brain structural changes have been tied to behavioural alterations noted in transgenic mice with targeting of different genes. Hence, we assess the brain structure of MOP-KO mice.