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Single housing during early adolescence causes time‐, area‐ and peptide‐specific alterations in endogenous opioids of rat brain
Author(s) -
Granholm L,
Roman E,
Nylander I
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12753
Subject(s) - nociceptin receptor , nucleus accumbens , dynorphin , endogenous opioid , opioid peptide , medicine , endocrinology , opioid , periaqueductal gray , amygdala , maternal deprivation , central nucleus of the amygdala , hypothalamus , locus coeruleus , ventral tegmental area , neuroscience , psychology , dopamine , central nervous system , receptor , dopaminergic , midbrain
A number of experimental procedures require single housing to assess individual behaviour and physiological responses to pharmacological treatments. The endogenous opioids are closely linked to social interaction, especially early in life, and disturbance in the social environment may affect opioid peptides and thereby confound experimental outcome. The aim of the present study was to examine time-dependent effects of single housing on opioid peptides in rats.