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Retracted : Rutin protects against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion
Author(s) -
Qu Jie,
Zhou Qiong,
Du Ying,
Zhang Wei,
Bai Miao,
Zhang Zhuo,
Xi Ye,
Li Zhuyi,
Miao Jianting
Publication year - 2014
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12725
Subject(s) - rutin , neuroprotection , medicine , dementia , vascular dementia , pharmacology , cerebral cortex , hippocampus , brain damage , neuroscience , anesthesia , psychology , antioxidant , disease , chemistry , biochemistry
Background and Purpose Chronic cerebral hypoperfusion is a critical causative factor for the development of cognitive decline and dementia in the elderly, which involves many pathophysiological processes. Consequently, inhibition of several pathophysiological pathways is an attractive therapeutic strategy for this disorder. Rutin, a biologically active flavonoid, protects the brain against several insults through its antioxidant and anti‐inflammatory properties, but its effect on cognitive deficits and brain damage caused by chronic cerebral hypoperfusion remains unknown. Here, we investigated the neuroprotective effect of rutin on cognitive impairments and the potential mechanisms underlying its action in rats with chronic cerebral hypoperfusion. Experimental Approach We used Sprague‐Dawley rats with permanent bilateral common carotid artery occlusion ( BCCAO ), a well‐established model of chronic cerebral hypoperfusion. After rutin treatment for 12 weeks, the neuroprotective effect of rutin in rats was evaluated by behavioural tests, biochemical and histopathological analyses. Key Results BCCAO rats showed marked cognitive deficits, which were improved by rutin treatment. Moreover, BCCAO rats exhibited central cholinergic dysfunction, oxidative damage, inflammatory responses and neuronal damage in the cerebral cortex and hippocampus, compared with sham‐operated rats. All these effects were significantly alleviated by treatment with rutin. Conclusion and Implications Our results provide new insights into the pharmacological actions of rutin and suggest that rutin has multi‐targeted therapeutical potential on cognitive deficits associated with conditions with chronic cerebral hypoperfusion such as vascular dementia and A lzheimer's disease.