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Does PKC activation increase the homologous desensitization of μ opioid receptors?
Author(s) -
Arttamangkul Seksiri,
Birdsong William,
Williams John T
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12712
Subject(s) - muscarine , desensitization (medicine) , homologous desensitization , chemistry , μ opioid receptor , receptor , protein kinase c , hyperpolarization (physics) , enkephalin , locus coeruleus , damgo , agonist , staurosporine , endocrinology , medicine , biophysics , pharmacology , opioid , signal transduction , biology , biochemistry , muscarinic acetylcholine receptor , central nervous system , stereochemistry , nuclear magnetic resonance spectroscopy
This study examined the role of agents known to activate PKC on morphine-induced desensitization of μ-opioid receptors (MOP receptors) in brain slices containing locus coeruleus neurons.