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Morphine‐induced internalization of the L 83 I mutant of the rat μ‐opioid receptor
Author(s) -
Cooke A E,
Oldfield S,
Krasel C,
Mundell S J,
Henderson G,
Kelly E
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12709
Subject(s) - internalization , g protein coupled receptor , opioid receptor , receptor , microbiology and biotechnology , agonist , enzyme linked receptor , μ opioid receptor , hek 293 cells , opioid , endocytic cycle , 5 ht5a receptor , arrestin , δ opioid receptor , chemistry , g protein , biology , damgo , signal transduction , endocytosis , biochemistry
Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic trafficking of the μ-opioid receptor (MOP receptor) is of great importance given its implication in the development of opioid tolerance. This study has compared the agonist-dependent trafficking and signalling of L83I, the rat orthologue of a naturally occurring variant of the MOP receptor.