Morphine‐induced internalization of the  L 83 I  mutant of the rat μ‐opioid receptor | Zendy

Cooke A E | Zendy; Oldfield S | Zendy; Krasel C | Zendy; Mundell S J | Zendy; Henderson G | Zendy; Kelly E | Zendy

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Morphine‐induced internalization of the L 83 I mutant of the rat μ‐opioid receptor

Author(s) -

Cooke A E,

Oldfield S,

Krasel C,

Mundell S J,

Henderson G,

Kelly E

Publication year - 2015

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.12709

Subject(s) - internalization , g protein coupled receptor , opioid receptor , receptor , microbiology and biotechnology , agonist , enzyme linked receptor , μ opioid receptor , hek 293 cells , opioid , endocytic cycle , 5 ht5a receptor , arrestin , δ opioid receptor , chemistry , g protein , biology , damgo , signal transduction , endocytosis , biochemistry

Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic trafficking of the μ-opioid receptor (MOP receptor) is of great importance given its implication in the development of opioid tolerance. This study has compared the agonist-dependent trafficking and signalling of L83I, the rat orthologue of a naturally occurring variant of the MOP receptor.

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