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Change in functional selectivity of morphine with the development of antinociceptive tolerance
Author(s) -
Macey T A,
Bobeck E N,
Suchland K L,
Morgan M M,
Ingram S L
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12703
Subject(s) - morphine , dynamin , opioid , pharmacology , chemistry , agonist , mapk/erk pathway , receptor , opioid receptor , signal transduction , medicine , endocytosis , biochemistry
Opioids, such as morphine, are the most effective treatment for pain but their efficacy is diminished with the development of tolerance following repeated administration. Recently, we found that morphine activated ERK in opioid-tolerant but not in naïve rats, suggesting that morphine activation of μ-opioid receptors is altered following repeated morphine administration. Here, we have tested the hypothesis that μ-opioid receptor activation of ERK in the ventrolateral periaqueductal gray (vlPAG) is dependent on dynamin, a protein implicated in receptor endocytosis.