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In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile
Author(s) -
Kuo A,
Wyse B D,
Meutermans W,
Smith M T
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12696
Subject(s) - oxycodone , buprenorphine , morphine , fentanyl , medicine , opioid , pharmacology , oxymorphone , anesthesia , receptor
For patients experiencing inadequate analgesia and intolerable opioid-related side effects on one strong opioid analgesic, pain relief with acceptable tolerability is often achieved by rotation to a second strong opioid. These observations suggest subtle pharmacodynamic differences between opioids in vivo. This study in rats was designed to assess differences between opioids in their in vivo profiles.