Pharmacology and anti‐addiction effects of the novel κ opioid receptor agonist  M esyl  S al  B , a potent and long‐acting analogue of salvinorin  A | Zendy

Simonson B | Zendy; Morani A S | Zendy; Ewald A W M | Zendy; Walker L | Zendy; Kumar N | Zendy; Simpson D | Zendy; Miller J H | Zendy; Prisinzano T E | Zendy; Kivell B M | Zendy

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Pharmacology and anti‐addiction effects of the novel κ opioid receptor agonist M esyl S al B , a potent and long‐acting analogue of salvinorin A

Author(s) -

Simonson B,

Morani A S,

Ewald A W M,

Walker L,

Kumar N,

Simpson D,

Miller J H,

Prisinzano T E,

Kivell B M

Publication year - 2015

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.12692

Subject(s) - pharmacology , agonist , functional selectivity , opioid , chemistry , receptor , dopamine transporter , opioid receptor , dopamine , medicine , biochemistry , dopaminergic

Acute activation of κ opioid (KOP) receptors results in anticocaine-like effects, but adverse effects, such as dysphoria, aversion, sedation and depression, limit their clinical development. Salvinorin A, isolated from the plant Salvia divinorum, and its semi-synthetic analogues have been shown to have potent KOP receptor agonist activity and may induce a unique response with similar anticocaine addiction effects as the classic KOP receptor agonists, but with a different side effect profile.

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