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Pharmacology and anti‐addiction effects of the novel κ opioid receptor agonist M esyl S al B , a potent and long‐acting analogue of salvinorin A
Author(s) -
Simonson B,
Morani A S,
Ewald A W M,
Walker L,
Kumar N,
Simpson D,
Miller J H,
Prisinzano T E,
Kivell B M
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12692
Subject(s) - pharmacology , agonist , functional selectivity , chemistry , opioid , dopamine transporter , receptor , opioid receptor , medicine , transporter , biochemistry , gene
Acute activation of κ opioid (KOP) receptors results in anticocaine-like effects, but adverse effects, such as dysphoria, aversion, sedation and depression, limit their clinical development. Salvinorin A, isolated from the plant Salvia divinorum, and its semi-synthetic analogues have been shown to have potent KOP receptor agonist activity and may induce a unique response with similar anticocaine addiction effects as the classic KOP receptor agonists, but with a different side effect profile.