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β‐Arrestin‐2 knockout prevents development of cellular μ‐opioid receptor tolerance but does not affect opioid‐withdrawal‐related adaptations in single PAG neurons
Author(s) -
Connor M,
Bagley E E,
Chieng B C,
Christie M J
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12673
Subject(s) - nociception , gene knockout , opioid , knockout mouse , opioid receptor , neuroscience , morphine , pharmacology , chemistry , damgo , receptor , medicine , biology , biochemistry , gene
Tolerance to the behavioural effects of morphine is blunted in β-arrestin-2 knockout mice, but opioid withdrawal is largely unaffected. The cellular mechanisms of tolerance have been studied in some neurons from β-arrestin-2 knockouts, but tolerance and withdrawal mechanisms have not been examined at the cellular level in periaqueductal grey (PAG) neurons, which are crucial for central tolerance and withdrawal phenomena.