Premium
Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7
Author(s) -
Bäck Magnus,
Powell William S,
Dahlén SvenErik,
Drazen Jeffrey M,
Evans Jilly F,
Serhan Charles N,
Shimizu Takao,
Yokomizo Takehiko,
Rovati G Enrico
Publication year - 2014
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12665
Subject(s) - receptor , lipid signaling , g protein coupled receptor , chemistry , inflammation , leukotriene b4 , pharmacology , biochemistry , microbiology and biotechnology , biology , immunology
The endogenous ligands for the LT , lipoxin ( LX ) and oxoeicosanoid receptors are bioactive products produced by the action of the lipoxygenase family of enzymes. The LT receptors BLT 1 and BLT 2 , are activated by LTB 4 and the CysLT 1 and CysLT 2 receptors are activated by the cysteinyl‐ LTs , whereas oxoeicosanoids exert their action through the OXE receptor. In contrast to these pro‐inflammatory mediators, LX A 4 transduces responses associated with the resolution of inflammation through the receptor FPR 2/ ALX ( ALX / FPR 2). The aim of the present review is to give a state of the field on these receptors, with focus on recent important findings. For example, BLT 1 receptor signalling in cancer and the dual role of the BLT 2 receptor in pro‐ and anti‐inflammatory actions have added more complexity to lipid mediator signalling. Furthermore, a cross‐talk between the CysLT and P 2 Y receptor systems has been described, and also the presence of novel receptors for cysteinyl‐ LTs , such as GPR 17 and GPR 99. Finally, lipoxygenase metabolites derived from ω‐3 essential polyunsaturated acids, the resolvins, activate the receptors GPR 32 and C hem R 23. In conclusion, the receptors for the lipoxygenase products make up a sophisticated and tightly controlled system of endogenous pro‐ and anti‐inflammatory signalling in physiology and pathology.