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The μ‐opioid receptor: an electrophysiologist's perspective from the sharp end
Author(s) -
Henderson Graeme
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12633
Subject(s) - opioid , neuroscience , morphine , opioid receptor , receptor , electrophysiology , medicine , pharmacology , peripheral , perspective (graphical) , psychology , computer science , artificial intelligence
Morphine, the prototypical opioid analgesic drug, produces its behavioural effects primarily through activation of μ-opioid receptors expressed in neurones of the central and peripheral nervous systems. This perspective provides a historical view of how, over the past 40 years, the use of electrophysiological recording techniques has helped to reveal the molecular mechanisms by which acute and chronic activation of μ-opioid receptors by morphine and other opioid drugs modify neuronal function.