Functional selectivity and time‐dependence of μ‐opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area | Zendy

Lowe J D | Zendy; Bailey C P | Zendy

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Functional selectivity and time‐dependence of μ‐opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area

Author(s) -

Lowe J D,

Bailey C P

Publication year - 2015

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.12605

Subject(s) - desensitization (medicine) , damgo , agonist , homologous desensitization , chemistry , enkephalin , ventral tegmental area , pharmacology , μ opioid receptor , neuroscience , opioid , receptor , endocrinology , medicine , opioid receptor , biology , biochemistry , dopaminergic , dopamine

The majority of studies examining desensitization of the μ-opioid receptor (MOR) have examined those located at cell bodies. However, MORs are extensively expressed at nerve terminals throughout the mammalian nervous system. This study is designed to investigate agonist-induced MOR desensitization at nerve terminals in the mouse ventral tegmental area (VTA).

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