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Functional selectivity and time‐dependence of μ‐opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area
Author(s) -
Lowe J D,
Bailey C P
Publication year - 2015
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12605
Subject(s) - desensitization (medicine) , damgo , agonist , homologous desensitization , chemistry , enkephalin , ventral tegmental area , pharmacology , μ opioid receptor , neuroscience , opioid , receptor , endocrinology , medicine , opioid receptor , biology , biochemistry , dopaminergic , dopamine
The majority of studies examining desensitization of the μ-opioid receptor (MOR) have examined those located at cell bodies. However, MORs are extensively expressed at nerve terminals throughout the mammalian nervous system. This study is designed to investigate agonist-induced MOR desensitization at nerve terminals in the mouse ventral tegmental area (VTA).