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High hopes for CB 2 receptors in neurogenesis
Author(s) -
Downer Eric J
Publication year - 2014
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12548
Subject(s) - subgranular zone , neurogenesis , subventricular zone , dentate gyrus , neuroscience , hippocampal formation , hippocampus , neural stem cell , lateral ventricles , biology , mammalian brain , stem cell , microbiology and biotechnology
During life, new neurons are continually added to hippocampal circuitry, with evidence suggesting that these adult-born neurons are functionally linked to cognition and emotion. The mammalian brain contains actively dividing neural stem cells in discrete regions, including the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus. Once mature, these neurons integrate into neuronal networks, forming synaptic connections with interneurons, mossy cells and CA3 pyramidal cells