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The genetic ablation or pharmacological inhibition of TRPV1 signalling is beneficial for the restoration of quiescent osteoclast activity in ovariectomized mice
Author(s) -
Rossi F,
Bellini G,
Torella M,
Tortora C,
Manzo I,
Giordano C,
Guida F,
Luongo L,
Papale F,
Rosso F,
Nobili B,
Maione S
Publication year - 2014
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12542
Subject(s) - trpv1 , osteoclast , endocannabinoid system , bone resorption , ovariectomized rat , endocrinology , medicine , receptor , chemistry , in vivo , osteoporosis , microbiology and biotechnology , transient receptor potential channel , biology , estrogen
Osteoporosis is a condition characterized by a decrease in bone density, which decreases its strength and results in fragile bones. The endocannabinoid/endovanilloid system has been shown to be involved in the regulation of skeletal remodelling. The aim of this study was to investigate the possible modulation of bone mass mediated by the transient receptor potential vanilloid type 1 channel (TRPV1) in vivo and in vitro.