Drp 1 is dispensable for apoptotic cytochrome  c  release in primed  MCF 10 A  and fibroblast cells but affects  Bcl ‐2 antagonist‐induced respiratory changes | Zendy

Clerc P | Zendy; Ge S X | Zendy; Hwang H | Zendy; Waddell J | Zendy; Roelofs B A | Zendy; Karbowski M | Zendy; Sesaki H | Zendy; Polster B M | Zendy

Premium

Drp 1 is dispensable for apoptotic cytochrome c release in primed MCF 10 A and fibroblast cells but affects Bcl ‐2 antagonist‐induced respiratory changes

Author(s) -

Clerc P,

Ge S X,

Hwang H,

Waddell J,

Roelofs B A,

Karbowski M,

Sesaki H,

Polster B M

Publication year - 2014

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.12515

Subject(s) - cytochrome c , apoptosis , biology , programmed cell death , cytochrome , microbiology and biotechnology , apoptosome , biochemistry , caspase , enzyme

Dynamin-related protein 1 (Drp1) mediates mitochondrial fission and is thought to promote Bax/Bak-induced cytochrome c release during apoptosis. Conformationally active Bax, Bak and Bax/Bak-activating BH3-only proteins, such as Bim, are restrained by anti-apoptotic Bcl-2 proteins in cells that are 'primed for death'. Inhibition of Bcl-2/Bcl-xL/Bcl-w by the antagonist ABT-737 causes rapid apoptosis of primed cells. Hence, we determined whether Drp1 is required for cytochrome c release, respiratory alterations and apoptosis of cells that are already primed for death.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research