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A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response‐related difference in mitochondrial networks
Author(s) -
Villaseñor A,
Ramamoorthy A,
Silva dos Santos M,
Lorenzo M P,
Laje G,
Zarate C,
Barbas C,
Wainer I W
Publication year - 2014
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.12494
Subject(s) - depression (economics) , ketamine , bipolar disorder , medicine , metabolomics , plasma levels , pharmacology , psychology , neuroscience , bioinformatics , psychiatry , biology , mood , macroeconomics , economics
(R,S)-ketamine produces rapid and significant antidepressant effects in approximately 65% of patients suffering from treatment-resistant bipolar depression (BD). The genetic, pharmacological and biochemical differences between ketamine responders and non-responders have not been identified. The purpose of this study was to employ a metabolomics approach, a global, non-targeted determination of endogenous metabolic patterns, to identify potential markers of ketamine response and non-response.