A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response‐related difference in mitochondrial networks | Zendy

Villaseñor A | Zendy; Ramamoorthy A | Zendy; Silva dos Santos M | Zendy; Lorenzo M P | Zendy; Laje G | Zendy; Zarate C | Zendy; Barbas C | Zendy; Wainer I W | Zendy

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A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response‐related difference in mitochondrial networks

Author(s) -

Villaseñor A,

Ramamoorthy A,

Silva dos Santos M,

Lorenzo M P,

Laje G,

Zarate C,

Barbas C,

Wainer I W

Publication year - 2014

Publication title -

british journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.432

H-Index - 211

eISSN - 1476-5381

pISSN - 0007-1188

DOI - 10.1111/bph.12494

Subject(s) - depression (economics) , ketamine , bipolar disorder , medicine , metabolomics , plasma levels , pharmacology , psychology , neuroscience , bioinformatics , psychiatry , biology , mood , macroeconomics , economics

(R,S)-ketamine produces rapid and significant antidepressant effects in approximately 65% of patients suffering from treatment-resistant bipolar depression (BD). The genetic, pharmacological and biochemical differences between ketamine responders and non-responders have not been identified. The purpose of this study was to employ a metabolomics approach, a global, non-targeted determination of endogenous metabolic patterns, to identify potential markers of ketamine response and non-response.

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